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We included the STN as a hidden node in the network, given our limited spatial resolution. In this way, we incorporated the influence of STN onto the network given its location within the circuit, without using the own region’s measured BOLD signal ( Kahan et al. , 2014 ). We verified that addition of the STN as a hidden node did not critically influence our results, by repeating the analyses without the STN (i.e. by directly connecting the GPi to the GPe via an inhibitory connection). This gave the same results: the model where dopamine influenced the VIM was significantly stronger than all others (protected exceedance probability of >98%).

Head motion may be a major confound when comparing functional MRI data across sessions. However, head motion did not significantly differ between sessions, subjects did not abruptly move their heads during scanning, and we regressed out motion artefacts by including a global signal ( Power et al. , 2014 ) and an extensive set of movement parameters into our analysis ( Lund et al. , 2005 ). Thus, we are confident that our results are not biased by motion artefacts.

The nature of our study prevented us from using a group of healthy subjects as control group. However, our main aim was to test for the interaction between dopamine and tremor-related activity, and this interaction cannot be tested in subjects without tremor (i.e. healthy controls). A previous study has shown that tremor-related activity in Parkinson’s disease patients is different from activity related to mimicked tremor in healthy subjects ( Muthuraman et al. , 2012 ). This difference may relate to the fact that resting tremor in Parkinson’s disease is involuntary, whereas mimicked tremor is voluntary per definition. Furthermore, investigating what the influence of dopamine is on a voluntary-related tremor network in healthy, non-dopamine depleted subjects seems even more problematic.

The results of a DCM analysis depend explicitly upon the models evaluated. Here we contrasted different models where dopamine modulates a single node or a single effective connection. Thus, we tested where in the circuit dopamine has the largest effect, rather than exploring all possible modulations within our model.

The findings suggest that dopamine controls Parkinson’s tremor by acting on the cerebellar thalamus (VIM) and on the pallidum. We propose that dopamine suppresses resting tremor by potentiating thalamic inhibition, thereby preventing tremor amplification in this region. This contradicts the hypothesis that tremor is caused by thalamic hyperpolarization, i.e. increased inhibition. We propose that patients with a relatively dopamine-resistant tremor have impaired dopaminergic control over the thalamus, possibly due to changes in other neurotransmitter systems.

M.D. and R.H. were funded by a grant of the Dutch Brain Foundation (grant F2013(1)-15 to R.H.). H.d.O. was supported by a Research Veni Grant from the Innovational Research Incentives Scheme of the Netherlands Organisation for Scientific Research.

EntroPay is a convenient and secure way for online poker players to send and receive money at online poker rooms in just a few clicks. It is an especially handy way of depositing funds onto your favorite internet cardroom , especially if you are playing at more than one site. Check out this page for more information on the best EntroPay poker sites out there today.

EntroPay

In the year 2000, EntroPay actually became the first virtual prepaid card provider in Europe. It is essentially a virtual debit card you can use to pay for things on the Internet, just without the “plastic card.” They offer Visa and MasterCard prepaid cards which both work in much the same way. EntroPay is authorized and regulated by the Financial Conduct Authority (FCA) as an online payment services provider.

Best Entropay Online Poker Rooms

To deposit into EntroPay poker sites first requires you to register for an EntroPay account and fund your EntroPay Virtual Card by loading funds from your personal credit or debit card that you would like to use as your funding source.

Signing up at EntroPay is free and easy to do. You can do this by clicking on the “Sign Up” link, which is located at the top of the homepage of EntroPay’s website. The registration forms will ask for your personal details, including your name, date of birth, e-mail address, country of residence, and username/password for the account.

After registering an account at the EntroPay site, you’ll receive a 16-digit “card” number to use for any online payments where this method is accepted.

From there, you will then need to login to your EntroPay account to link your debit or credit card. They accept all major credit cards (any with a Visa, MasterCard or Maestro logo on it.) You can also link your bank account if you would prefer to do that.

Once your EntroPay account is loaded with funds, you can then head over to the ‘Cashier’ section of your favorite EntroPay poker site to make a deposit, allowing you to start playing online poker games for real money in no time at all.

You can also apply for the “EntroPay Plastic MasterCard” which can be used both online and offline merchants. Owning the EntroPay plastic card will also allow you to instantly access your funds at ATMs.

One of the advantages of using an EntroPay prepaid card to fund your account is that it keeps your transactions with online poker sites private, since you do not need to reveal any financial information to the poker room. The EntroPay site also boasts the TRUSTe seal to indicate its commitment to privacy. You can have the peace of mind in knowing that all members’ confidential information is kept safe.

Unlike other prepaid card options, it’s a virtual prepaid card which can be easily purchased on Entropay’s website, so you don’t have to go anywhere to load funds onto your card. Since it’s a prepaid funding option, it also helps you to manage your finances better, as you can’t lose more than the amount you deposited onto your EntroPay virtual prepaid card.

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